19 Jan Treating Benign Prostatic Hypertrophy (BPH)
If you have Benign Prostatic Hypertrophy (BPH), you know its inconvenient, annoying, and at times very serious symptoms. Benign prostatic hypertrophy is an enlargement of the prostate gland. The prostate is a gland that surrounds the urethra, sits just below the bladder, and makes semen. In men with BPH, the prostate can become significantly larger and cause urinary obstruction. In most men, BPH causes no recognizable symptoms. But about one-third of American men can experience the following symptoms:
- An urge to urinate more than two times per night (nocturia).
- A weak urine stream that starts and stops.
- Feeling that you still must urinate even after you just finished.
- Trouble initiating a urine stream (hesitancy).
- The presence of blood in the urine (hematuria).
Over time, BPH can lead to more serious problems such as urinary tract infections, kidney, and bladder damage. This happens when the obstruction causes urine to backup which damages the kidney and bladder.
Approximately 42% of men aged 51 to 60 years have BPH. Approximately 90% of men aged 45 to 80 years have lower urinary tract symptoms or LUTS. The occurrence of LUTS increases with age for almost all racial and ethnic groups with prevalence highest among Hispanic men, then Blacks, Caucasians, and Asians.
Men with symptomatic BPH typically receive two types of medications, alpha-blockers, and 5-alpha-reductase inhibitors.
Alpha-blockers relax the smooth muscle in the bladder neck and prostate to improve urine flow and relieve urinary obstruction. 5-alpha-reductase inhibitors target the hormonal aspects of BPH and not only help with urinary flow, but if taken long enough, can actually shrink the prostate and postpone the need for surgery. The effects of these two types of medications have a greater effect when used together.
Adding Tadalafil (Cialis®) to the treatment program.
What does the science say?
The rationale for using Cialis® for BPH stems from the following three observations. First, the prevalence of lower urinary tract symptoms (LUTS), BPH, and erectile dysfunction (ED) increases with age; second, the use of Cialis® causes smooth muscle relaxation in the lower urinary tract; and third, early clinical evidence demonstrates that medications such as Cialis® are successful in treating LUTS and ED. The method of action of Cialis® may not only involve different areas of the lower urinary tract such as smooth muscle cell relaxation in the bladder neck, prostate, and urethra but there may also be support for the healthy function of the nerves involved.
Cialis® at 5mg dose once daily for 12 weeks resulted in a clinically meaningful reduction in total in symptoms as early as 1 week and achieved significant improvement at 4 weeks. The ability to treat both BPH and ED with one medication is important given the significant negative impact in the quality of life these conditions have in aging men.
Are there side-effects to the use of Cialis™ in the treatment of BPH?
Numerous clinical studies show that Cialis® or it’s generic equivalent Tadalafil represents a well-tolerated and effective treatment option in men with moderate to severe BPH. Thirteen publications involving a total of 3,973 patients were used in an analysis of studies, known as a “meta-analysis”. What was found was that Cialis® at a dose of 5mg once daily was effective in improving symptoms of BPH and treating ED over 12 weeks. This analysis of numerous studies indicated Cialis® to be an effective treatment with a low occurrence of side effects.
If you are experiencing BPH and sexual difficulties secondary to your current medications and aren’t already on Cialis® or its generic equivalent Tadalafil, talk with your primary care doctor or urologist about adding Cialis® to your treatment program. It has been shown to be effective, safe with a low occurrence of side-effects and may not only help with the symptoms of BPH but also possibly improve your sex life.
How to get started?
The first step is to have your blood work done and the results evaluated by a healthcare professional experienced in BPH supportive therapy.
If you are experiencing any of the symptoms mentioned here, call Peak Male Institute at 941-203-8944 and schedule a consultation with one of our clinicians experienced in Benign Prostatic Hypertrophy (BPH) supportive therapy or SEND US A NOTE or better yet Find us on Google Maps.
What is a generic equivalent?
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Recent studies clearly highlight how beneficial a medically supervised, individually prescribed, and monitored therapeutic dose of Tadalafil (Cialis®) may be for prostate and libido health. Therefore, for a limited time, we are providing the medication at NO COST for those patients who qualify.
Offer Expires February 15th!
- “How Tadalafil Helps With Benign Prostatic Hyperplasia.” Naveed Saleh, MD, MS. Updated on April 23, 2020. Medically reviewed by Matthew Wosnitzer, MD.
- “Tadalafil for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia.” Ricardo R Gonzalez, Steven A Kaplan. Expert Opin Drug Metab Toxicol. 2006 Aug;2(4):609-17. doi: 10.1517/17425255.2.4.609.
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- “Administration of daily 5 mg tadalafil improves endothelial function in patients with benign prostatic hyperplasia.” Toshiyasu Amano, Carolyn Earle, Tetsuya Imao, Yuki Matsumoto, Takahiro Kishikage. Aging Male. 2018 Mar;21(1):77-82. doi: 10.1080/13685538.2017.1367922. Epub 2017 Aug 22.
- “Tadalafil Improves Symptoms, Erectile Function and Quality of Life in Patients with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia.” (KYU-PRO Study). Ryosuke Takahashi, Minoru Miyazato, Hisae Nishii, Yasuhiro Sumino, Kazuo Takayama, Masako Onzuka, Takuma Oshiro, Seiichi Saito, Naohiro Fujimoto, Hiromitsu Mimata, Masatoshi Eto
- “Tadalafil Ameliorates Symptoms of Patients with Benign Prostatic Hyperplasia Complicated by Chronic Pelvic Pain Syndrome.” Yoshinori Nishino, Kousei Miwa, Yoji Moriyama, Shigeru Fujihiro, Takako Masue, Mina Kikuchi, Chie Nakai, Takashi Deguchi. Hinyokika Kiyo. 2017 Mar;63(3):101-105. doi: 10.14989/ActaUrolJap_63_3_101.
- “Efficacy and safety of tadalafil 5 mg once daily in the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia in men aged ≥75 years: integrated analyses of pooled data from multinational, randomized, placebo-controlled clinical studies.” Matthias Oelke, Adrian Wagg, Yasushi Takita, Hartwig Büttner, Lars Viktrup. BJU Int. 2017 May;119(5):793-803. doi: 10.1111/bju.13744. Epub 2017 Jan 22.
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- “Tadalafil 5 mg Once Daily Improves Lower Urinary Tract Symptoms and Erectile Dysfunction: A Systematic Review and Meta-analysis.” Yilin Wang, Yiping Bao, Jie Liu, Lijun Duan, Yuanshan Cui. Low Urin Tract Symptoms. 2018 Jan;10(1):84-92. doi: 10.1111/luts.12144. Epub 2016 Nov 5.
- “Effects of tadalafil on lower urinary tract symptoms secondary to benign prostatic hyperplasia and on erectile dysfunction in sexually active men with both conditions: analyses of pooled data from four randomized, placebo-controlled tadalafil clinical studies.” Hartmut Porst, Claus G Roehrborn, Roberta J Secrest, Anne Esler, Lars Viktrup. J Sex Med. 2013 Aug;10(8):2044-52. doi: 10.1111/jsm.12212. Epub 2013 Jun 19.
- “Tadalafil once daily in the treatment of lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH) in men without erectile dysfunction.” Gerald Brock, Gregory Broderick, Claus G Roehrborn, Lei Xu, David Wong, Lars Viktrup. Eur Urol. 2011 Nov;60(5):1105-13. doi: 10.1016/j.eururo.2011.08.005. Epub 2011 Aug 12.
- “Efficacy and safety of tadalafil once daily in the treatment of men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: results of an international randomized, double-blind, placebo-controlled trial.” Hartmut Porst, Edward D Kim, Adolfo R Casabé, Vincenzo Mirone, Roberta J Secrest, Lei Xu, David P Sundin, Lars Viktrup, LVHJ study team. BJU Int. 2013 Nov;112(7):990-7. doi: 10.1111/bju.12251. Epub 2013 Aug 13.